Fig. 4

CA140 administration reduces NLRP3, IL-1β levels and reactive gliosis in 8-month-old 5xFAD mice. A–H Eight-month-old 5xFAD mice were injected with vehicle (10% DMSO) or CA140 (30 mg/kg, i.p.) daily for 14 days, and immunofluorescence staining of brain slices was performed with anti-NLRP3 (A, B), anti-IL-1β (C, D), anti-CXCL10 (E, F) and anti-C1QA (G, H) antibodies (n = 16–23 brain slices from 4 mice). Scale bar = 200 μm. *p < 0.05, **p < 0.01, ***p < 0.001