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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy

Fig. 8

The inhibition of NETs formation alleviated the AJs disruption may by regulating VCL/β-catenin/VE-cadherin functional complex. A Triple labeling IF staining showed colocalization of VCL, β-catenin and VE-cadherin (n = 6); Quantification of the fluorescence intensity of VCL (B), β-catenin (C) and VE-cadherin (D) in the hippocampus (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; IF: immunofluorescence. (ns: no significance, *p < 0.05, **p < 0.01, ***p < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094