Table 2 Fructose metabolism-related signatures in microglia across AD and AD-related models
From: Do microglia metabolize fructose in Alzheimer’s disease?
Model | Species | Analysis Method | Differentially Regulated Pathways & Genes | References |
|---|---|---|---|---|
5xFAD microglia, 8 months | Mouse | scRNA-seq, snRNA-seq | Up: Slc2a5 | Narges et al., 2024 [38] |
LOAD vs. non-demented brain, PFC | Human | Bayesian network derived co-expression modules | Up: Immune / microglia cells (SLC2A5) | Zhang et al., 2013 [37] |
Monocyte-derived microglia-like cells, 55 year old female | Human | rtPCR | Up: SLC2A5 | Cleland et al., 2024 [65] |
Cd11b+ microglia, 20 month old females | Mouse | Bulk RNAseq | Up: Slc2a5, Apoe | Cleland et al., 2024 [65] |
20% fructose-fed male brains, 35 days old | Rat | rtPCR IF staining | Up: Slc2a5 (whole brain) Up: Slc2a5 (hippocampus) | Shu et al., 2006 [126] |
20% fructose-fed male brains, 12 months | Rat | rtPCR | Up: Slc2a5 | Shu et al., 2006 [126] |
Senescence-Accelerated Mouse Prone 8 aging model, females | Mouse | CITE-seq | Up: Metabolism (Slc2a5, Apoe) | Gruel et al., 2024 [128] |
HSV-1 infected CD11b+ microglia, VPL | Mouse | scRNA-seq | Up: Carbohydrate derivative binding (Slc2a5) | Uyar et al., 2022 [120] |
VCD-induced menopausal hippocampus with human ApoE4, 8-12 month old females | Mice | rtPCR | Up: Metabolic/Bioenergetic (Aldob, Slc2a5) | Pontifex et al., 2022 [127] |
APPswe/PS1de9 cortical microglia, 15-18 month | Mouse | Expression profiling by array | Up: Aldoa, Slc2a1, Sord | Orre et al., 2014* [125] |
Down: Slc2a5, Slc2a1, Aldoc, Hk1, Hk3, Khk | ||||
Tau-P301S hippocampal CD11b+ cells, 6 months | Mouse | RNA-seq | Up: Aldoa | Friedman et al., 2018* [123] |
Down: Slc2a5 | ||||
Cortical CD11b+ cells from LPS injected mice | Mouse | RNA-seq | Up: Slc2a1 | Srinivasan et al., 2016* [122] |
Down: Slc2a5 |